@Reuters: President Joe Biden's top diplomat will seek to defuse a crisis with Moscow over Ukraine when he meets the Russian foreign minister in Geneva this week following visits with Ukrainian leaders in Kyiv and European officials in Berlin https://t.co/kFmWu1BTeN

2022.01.19 08:07 -en- @Reuters: President Joe Biden's top diplomat will seek to defuse a crisis with Moscow over Ukraine when he meets the Russian foreign minister in Geneva this week following visits with Ukrainian leaders in Kyiv and European officials in Berlin https://t.co/kFmWu1BTeN

@Reuters: President Joe Biden's top diplomat will seek to defuse a crisis with Moscow over Ukraine when he meets the Russian foreign minister in Geneva this week following visits with Ukrainian leaders in Kyiv and European officials in Berlin https://t.co/kFmWu1BTeN submitted by -en- to newsbotbot [link] [comments]


2022.01.19 08:07 haber-trend Sıcak! | 2. Asiye Ateş vakası! Köpekler 14 yaşındaki çocuğun yüzünü parçaladı #Kastamonu #Seydiler son saatin en çok aranan 17. trend haberi oldu ve an itibarıyla 8 gazetede yer alıyor.

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2022.01.19 08:07 DerpessionTime I got corona

Okay so, today i woke up with a sore throat, and i thought noting of it because i had a little sore throat yesterday, so i went to school.
At school i asked for a covid test and i got one. After i did the steps for the test i waited and i got one line so i thought i was in the clear, but as fate would have it after 5 minutes of waiting i checked it again and there was two lines on it. So i freaked out and put on a mask and went to another room to call home so they could come and get me.
After i got home i called the covid testing clinic and booked an appointment s i could come and get tested. I did the test at 11:30 am and now im at home and waiting for the result.
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2022.01.19 08:07 Bonus1Fact [Agitator & Misinformation] What Plato Would Have Thought About Licorice Pizza ¦ The Atlantic Magazine

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2022.01.19 08:07 -en- @Reuters: Factbox: How UK PM Johnson could be ousted by unhappy lawmakers https://t.co/dIy3gW1rdA https://t.co/YBykplCu0N

@Reuters: Factbox: How UK PM Johnson could be ousted by unhappy lawmakers https://t.co/dIy3gW1rdA https://t.co/YBykplCu0N submitted by -en- to newsbotbot [link] [comments]


2022.01.19 08:07 krishnaknt The irregular at Magic High School Season 1 English Dub is now available on Hulu!

The irregular at Magic High School Season 1 English Dub is now available on Hulu! https://www.hulu.com/series/the-irregular-at-magic-high-school-80e76834-7c30-45fe-bcaa-1f4ace6a99da

https://preview.redd.it/1moy6y54nmc81.jpg?width=741&format=pjpg&auto=webp&s=235642f9d80119480ada751bbd5816acbe8e3e49
submitted by krishnaknt to Mahouka [link] [comments]


2022.01.19 08:07 Git777 I have studied Dungeon Design for 3 years. This is what I have.

I am a vetran DM, I desided to make a mega dungeon and found no one could tell me where to start. Draw a map and come up with a list of monsters is not my idea of an engaging adventure.
This is a tool set and a description on how to use it. It is FAR from perfect. I need help making it better.
please read and enjoy.
https://docs.google.com/document/d/1tGrsYKQ5T0Ahk05tFj5P89SiklEIvZCU/edit?usp=sharing&ouid=104327408898618103829&rtpof=true&sd=true
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2022.01.19 08:07 TakingItOffHereBoss What fad died out that should have kept going?

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2022.01.19 08:07 -en- @Reuters: Big U.S. banks see higher expenses from workers' rising wages https://t.co/4ZzEU9pzqc https://t.co/qZOe7sTV5l

@Reuters: Big U.S. banks see higher expenses from workers' rising wages https://t.co/4ZzEU9pzqc https://t.co/qZOe7sTV5l submitted by -en- to newsbotbot [link] [comments]


2022.01.19 08:07 marv102 Starting Testavan treatment

I'm about to start Testavan treatment, one pump daily. Very excited and to get it on the NHS. Primary hypogonadism. T levels 7.4 nM. Very low libido. ED (am on 5 mg Tadalafil)
What do you think I can expect? Any changes you didn't expect or wouldn't necessarily think about? Did you suffer from acne or hair growth? (I have MPB). Did you have mood swings or improved mood/energy?
submitted by marv102 to Testosterone [link] [comments]


2022.01.19 08:07 PATASK_EVO Biofrontera - $BFRI - Letter to Shareholders - Bears and Bulls opinions welcome

To our valued stockholders,
(...)
The overarching strategy for Biofrontera’s success continues to be gaining market share for our two FDA-approved licensed products, Ameluz® and Xepi®, while also broadening our commercial opportunities through label expansions of our flagship product, Ameluz®.
(...) Our business rests upon license and supply agreements in the U.S. to market and sell Ameluz in combination with the red-light lamps BF-RhodoLED® and the new RhodoLED XL for the treatment of actinic keratosis (AK), as well as the topical antibiotic Xepi® for the treatment of impetigo.
In 2021, we created strong momentum that we expect will carry on into 2022, such as:

Commercial Momentum
We are proud of the hard work by the talented members of our sales team across the country. Despite the challenges resulting from the COVID-19 pandemic, we returned to topline growth in 2021. Most dermatology offices have fully reopened and patients have shown increased willingness to undergo in-office treatments for AK. We exited 2021 with strengthened financial performance, including:
Market Opportunity
According to the Skin Cancer Foundation, AK affects approximately 58 million people in the U.S. In 2020, an estimated 12.7 million AK treatments were performed in the U.S., which translates to a total addressable market of about $4 billion for Ameluz with its current FDA-approved indication. AK is a precursor to squamous cell carcinoma, a skin cancer with a potentially fatal outcome.
The most common treatment for AK is cryotherapy, with a 2020 market share of approximately 86%. Topical drugs for the treatment of AK had a market share of about 12%, followed by photodynamic therapy (PDT) treatments with about a 2% share. Despite its market dominance, we think cryotherapy lacks certain advantages as a treatment option compared with PDT. As such, the opportunity to gain share from cryotherapy is a key focus of our commercial efforts.
Expanding the Ameluz label allows us to consistently deliver innovative solutions for patients and serves as the key mechanism to unlock the drug’s potential. Continued investment in clinical research by our license partner aiming at label expansion is thus an integral part of our business. According to our license agreement for Ameluz®, the licensor is obliged to conduct and finance the clinical studies required for defined label expansions. The FDA approval pathway takes significant investment and time but, if successful, the result can be very rewarding – not only for the patients, but also for the potential value creation for our shareholders.
The clinical successes for our licensed products in 2021 included regulatory approval for the new RhodoLED XL lamp, progress on the Phase 3 study for the treatment of basal cell carcinoma (BCC), the launch of a 3-tube safety study as well as a Phase 2b trial for acne – all of which keep the Ameluz® clinical program moving forward.
Our second licensed prescription drug is Xepi®. Xepi® is a topical antibiotic for the treatment of impetigo, a highly contagious bacterial skin infection with more than 3 million cases in the U.S. each year. Currently, no antibiotic resistance against Xepi® is known, and Xepi has also been specifically approved by the FDA for resistant strains of staphylococcus aureus or streptococcus pyogenes, including MRSA.
In 2020, more than 13 million prescriptions were written for drugs in indications where Xepi® could be effective. Xepi® is distributed through specialty pharmacies and is generally covered by most commercial payers without pre-authorization. We believe there is considerable market potential for Xepi® in the coming years.
Strategies for Sustained Growth
Our longer-term financial objectives include achieving consistent revenue growth and expanding operating margins. Accordingly, we are focused on balancing market expansion with operating efficiency, including effective resource utilization, information technology leverage and overhead cost management.
Our market-expansion strategy is based on bolstering awareness of our licensed products through industry recognition, data-driven sales strategies, and a robust and dynamic commercial infrastructure. We intend to optimize our sales force by adding sales territories, and to strengthen medical affairs to become a trusted partner through scientific data publication, interaction with key opinion leaders (KOLs) and industry support. Overall, our marketing and development goals align to form a commercial strategy that has uniquely positioned Biofrontera for leadership in the treatment of dermatological conditions.
(...)
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2022.01.19 08:07 mexicofan isn’t there a first impressions or assumptions sub there has to be

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2022.01.19 08:07 chiccenj0y 1099-NEC

All I know is that I'm supposed to file by January 31st. This is my first time ever receiving a 1099. I do Flex as a side hustle and have only made $2k in 3 months. I've kept track of mileage and have all my expenses down. I just don't know how to get started? How do I file? What's the best website to file? Etc etc someone please help!
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2022.01.19 08:07 -en- @Reuters: An underwater volcano off Tonga erupts, triggering tsunami warnings and evacuation orders in Japan and causing large waves in several South Pacific islands, where footage on social media showed waves crashing into coastal homes https://t.co/LClABcF6FV https://t.co/HD26KsoUxP

@Reuters: An underwater volcano off Tonga erupts, triggering tsunami warnings and evacuation orders in Japan and causing large waves in several South Pacific islands, where footage on social media showed waves crashing into coastal homes https://t.co/LClABcF6FV https://t.co/HD26KsoUxP submitted by -en- to newsbotbot [link] [comments]


2022.01.19 08:07 tah_zem Top 10 Machine Translation APIs

Top 10 Machine Translation APIs submitted by tah_zem to TranslationStudies [link] [comments]


2022.01.19 08:07 Floor-Proof Quel reato voluto da Bonafede e che ora incastra il garante del M5s

Quel reato voluto da Bonafede e che ora incastra il garante del M5s submitted by Floor-Proof to news_italia [link] [comments]


2022.01.19 08:07 ThaMightyCunt LF : 5IV breedjects / FT : 5IV Jolly Natured Shroomish w Poison Heal ability and 4 egg moves

[TRADE]
Hello hello, I'm looking for 5IV breedjects and I've got some 5IV Shroomish to trade.
I have some 6IV Shroomish of the same nature as well, but I'd prefer to keep those for anyone trading their 6IV mons. Unfortunately the 6IV Shroomish only have 1 egg move (I didnt notice the egg move issue for a while, my bad)
Hit me up, happy trading.
submitted by ThaMightyCunt to pokemontrades [link] [comments]


2022.01.19 08:07 -en- @Reuters: Australian police charged a 32-year-old man with murder after the body of a nine-year-old girl, who went missing since while on holiday with family, was found in a barrel and dumped in a river near the Blue Mountains west of Sydney https://t.co/aJWp5Hb9zK https://t.co/E2sm4rhl0c

@Reuters: Australian police charged a 32-year-old man with murder after the body of a nine-year-old girl, who went missing since while on holiday with family, was found in a barrel and dumped in a river near the Blue Mountains west of Sydney https://t.co/aJWp5Hb9zK https://t.co/E2sm4rhl0c submitted by -en- to newsbotbot [link] [comments]


2022.01.19 08:07 jonassmile76 I WILL TELL YOU HOW TO OVERCOME THIS!

TLDR at the end!
Background story:
As a child, i used to stay at home all day long doing nothing. I had a TV that shows black and white screen and it shows children cartoons maybe 1 hour of the day. Actually a big part of my childhood i lived at a home even without a TV.
I used to get abused a lot, like when i say alot i mean it. My father did abuse me in all the physical and mental aspects possible. Mom on the other hand had this "Feminine mentality" Where she used to abuse me a lot as well and always stood with my sister in a way of her saying "You should not grow up and become abusive" but this Feminine mentality she had only broke me even more.
Only escape was from this extreme boredom is to create a reality. Where i was loved, appreciated, i was a king there! In other words I had control!
This became way worse after getting into school and getting a lot of abuse as well, and i was basically day dreaming all the time. It was the only place i had control.
I devolped OCD growing up, and i know maladaptive dreaming is highly linked to ADHD and OCD. So please remember, OCD and ADHD are side effects of living into the mind, this is my own experience. There are of course other more factors but this one is huge. I will explain more in a minute.
Why do we have this issue?
In easy words i would say It is an addiction to cope and an addiction can be cured so this is the good news. The bad news it is very hard because you are so indulged into your brain that it will feel weird to be present.
This addiction is you trying to escape a bad reality and trying to cope with bad emotions. Only way to heal this is by action. Thoughts are uselss if you can't take action on them. You need to stop 2 things: 1- Day dreaming, 2- Over talking.
Action is the master of all things, action is the boss. The dopamine that you get from achieving something is way higher than the dopamine you get from day dreaming for a long time.
3 steps to overcome this:
1- When your minds wander get back to the present, and train on this skill until you master it. (What i do is an Islamic Zikr which is a mantra in a way. I repeat Alhamdillah Alrahman Alrahim and i say it all the time, whenever my mind wanders, i redirect my focus to the Zikr and feel it's meaning)
2- Take action, if your job is boring then change it soon. Choose a job where you can be present.
3- Face your fears and show your mind who is boss.
This day dreaming thing is a sign of extreme weakness, the more you day dream the weaker you are. You need to build your self up.
Now to motivate you here are downsides from my own experience, from the internet, and what i think:
1- No more insomnia, you will feel that sleeping became easy if the day perior you were present.
2- Way less anxiety and OCD. The more present you are the less OCD
3- More focus and less ADHD
4- You enjoy things more. as you don't waste the dopamine reserve on day dreaming all day
5- You get the chance to do things more and courage increases ton fold.
6- Your discipline increases
7- Your mood become way better overall, while before you feel good only by day dreaming.
Music and movies are huge triggers for me so know yours!
Some day dreaming is very damaging: Not all day dreaming are the same, some are worse:
Fight fantasy: If you fantasize about fight for example (I have this one!) This is a sign of you getting bullied a lot. You need to prove yourself, but this is extremely damaging! Becuase you can get pshycial symptoms from it like headaches and other things. You sometimes feel the brain aches while doing it. Or numbness, so be careful with this one if you don't want a stroke.
Sexual fantasy: You are not supposed to be abusing other women/men in your mind. Sexual fantasy can have extreme mental issues that are way worse than any other one. The same year i started to ruminate about sex a lot, i get severe OCD and social anxiety, where i would be sitting in class and having this fear in my chest. I started sexual fantasy in the summer when i was 13 i get severe social anxiety when i started school 1 or 2 months after approximately. So i know 100% there is a link.
Music and movies are huge triggers for me so know yours!
TLDR: Day dreaming is a sign of a weak mind, a weak person. It is an addiction to cope with bad emotion. You need to deal with this, by improving the present mind, facing fears and taking action.
Hope you the best!
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2022.01.19 08:07 NewsElfForEnterprise Seastreak launched biggest high-speed commuter ferry in US, but COVID keeps it in dock

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2022.01.19 08:07 ked1022 WRAITH KING ABILITY REWORK

Q: Hurlbat
ABILITY:Unit Target / Target Point AFFECTS:Enemy Units DAMAGE TYPE:Magical PIERCES SPELL IMMUNITY:No DISPELLABLE:Strong Dispels Only
COOLDOWN: 17/14/11/8 MANA COST: 95/110/125/140 DAMAGE: 60/80/100/120 STUN DURATION: 1.1/1.4/1.7/2 SLOW DURATION: 2.0 MOVEMENT SLOW: -20% CAST POINT 0.35s
Wraith King hurls his sword in the targeted direction. The sword will boomerang back to Wraithking. If the sword hits an enemy hero, it deals damage and stuns, then slows the target.
Damage and stun duration scales with the distance the sword traveled before hitting the target:
50% at point blank range
100% at max range
150% at 'boomerang' range
*If Hurlbat hits a target, summoned wraiths will attack that target.
W: Spirit Shroud
ABILITY:No Target AFFECTS: Enemies/Self DAMAGE TYPE: Magical PIERCES SPELL IMMUNITY:No DISPELLABLE:Strong Dispels Only
COOLDOWN: 50 MANA COST: 70/80/90/100 HEALTH DRAIN PER SECOND: 0.5%/0.75%/1.0%/1.5% DAMAGE PER SECOND PER STACK: 10 MAX CHARGE: 2/4/6/8 WRAITH DURATION: 60 Wraith Explosion Damage: 50
Wraith King drains health from nearby enemies based on their Max HP. If enemies die from Spirit Shroud, Wraith King collects their Spirits. Each Spirit collected by Wraith King floats around him dealing damage to nearby enemies. Can be cast to summon Wraiths. Wraiths explode if killed or expire.
E: Mortal Strike
ABILITY: Point Target AFFECTS: Enemies/Allies/Self DAMAGE TYPE: Pure PIERCES SPELL IMMUNITY:Yes
COOLDOWN: 5.5/5/4.5/4 MANACOST: 40/50/60/70 BASE DAMAGE: 50 BONUS DAMAGE PER KILL: 1/2/3/4
Wraith King strikes his target, dealing additional damage as Pure Damage and heals Wraith King and nearby allies. Slaying the target permanently increases the damage of Mortal Strike.
R: Reincarnation
ABILITY:Passive AFFECTS:Enemies PIERCES SPELL IMMUNITY:No DISPELLABLE:Yes
COOLDOWN: 200/130/60 MANA COST: 160
Wraith King's form regroups after death, allowing him to resurrect when killed in battle. Upon death, enemy units in a 900 radius will be slowed.
*Shard and Scepter Upgrade remains the same.
submitted by ked1022 to DotaConcepts [link] [comments]


2022.01.19 08:07 Foreign_Wishbone3788 Stream quranlearnacademy music | Listen to songs, albums,playlistsforfreeonSoundCloud

Stream quranlearnacademy music | Listen to songs, albums,playlistsforfreeonSoundCloud submitted by Foreign_Wishbone3788 to Digitalmediadmt [link] [comments]


2022.01.19 08:07 NotDennisBonvie [Game Thread] Utica Comets (20-4-4) at Laval Rocket (14-11-2) - January 19th 2022

7:30 PM
Watch on RDS or AHLtv
Listen on FM 91.9 Sports or AM TSN 690 MTL
LET'S GO ROCKET! 🚀
submitted by NotDennisBonvie to lavalrocket [link] [comments]


2022.01.19 08:07 -en- @Reuters: Chip supplier ASML forecasts strong 2022 despite fire hit https://t.co/tySALNEI92 https://t.co/QmuQqKGsaZ

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